General Information

  • ID:  hor004806
  • Uniprot ID:  E2ADX8
  • Protein name:  Allatostatin A2
  • Gene name:  EAG_13122
  • Organism:  Camponotus floridanus (Florida carpenter ant)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  Allatostatins A1, A2 and A3 are expressed in brain, antennal lobes, optical lobes, gnathal ganglia, the retrocerebral complex and thoracic, abdominal and ventral ganglia. Allatostain A4 is expressed in brain (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Camponotus (genus), Camponotini (tribe), Formicinae (subfamily), Formicidae (family), Formicoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TRPFSFGI
  • Length:  8(87-94)
  • Propeptide:  MKTSSLIAMRLIIFYLLSVVGRSTAAVEEAPASSLHIPRLNPLSSNLEYDEPSEKRAYAYISEYKRLPLYNFGIGKRWIDNSEDKRTRPFSFGIGKRLRDYRFGIGKRNSGYRPLGMDFSVDNMDFHSREDNLDDFIDDKRGGQPFSFGIGKRGWKLPMGEMAVSGRRLNDVVGPKYLLGLGKGLSENENLIQ
  • Signal peptide:  MKTSSLIAMRLIIFYLLSVVGRSTA
  • Modification:  T8 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May act as a neurotransmitter or neuromodulator.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E2ADX8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004806_AF2.pdbhor004806_ESM.pdb

Physical Information

Mass: 104909 Formula: C44H65N11O11
Absent amino acids: ACDEHKLMNQVWY Common amino acids: F
pI: 10.55 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: 26.25 Boman Index: -907
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 48.75
Instability Index: 4628.75 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  25641051
  • Title:  Neuropeptidomics of the Carpenter Ant Camponotus Floridanus